Category Archives: Urgent Science

Kudos to Dr. Bestermann!

My good friend Bill Bestermann, MD, a preventive vascularist at the Holston Medical Group in Kingsport, TN, has published an important article in CardioRenal Medicine. This paper, a long time coming, is not research but a highly informed thought piece that … Continue reading

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Book Review – The Emperor of All Maladies: A Biography of Cancer

Brian’s Note: With yesterday’s announcement that Siddhartha Mukherjee’s The Emperor of All Maladies had won the Pulitzer for General Non-Fiction, I thought it might be appropriate to rerun this review from last December 5, 2010. BRIAN KLEPPER The opening page … Continue reading

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An Approach to Lipid Management in Patients with Cardiometabolic Risk

DAVID G. CARMOUCHE Note by Bill Bestermann, MD. Dr. David Carmouche works at the Baton Rouge Clinic in Baton Rouge, Louisiana.  He runs a Center for Cardiovascular Disease Prevention within the clinic and works full time in clinical practice producing … Continue reading

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Protocol Approach for IOM Priority Vascular Conditions

Brian’s Note: In the post below, Dr. Bestermann, a highly regarded vascular physician, has developed and posted a field-tested protocol for the treatment of vascular conditions deemed high priority by the Institute of Medicine. This is a work in progress … Continue reading

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The High Cost of Ignoring a Large Body of Specific Research Aimed at Women and Heart Disease

WILLIAM BESTERMANN There may be no more striking disconnect between new compelling science and current practice than we see in the treatment of women with chest pain.  Just today, I saw a woman in her early 50s who has had … Continue reading

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An Introduction to Metformin and Cancer

WILLIAM H. BESTERMANN The current scientific paradigms that shape our view of chronic conditions are simply inadequate. Clinical medical scientists might think much more seriously about questions like these: Why is it that metformin reduces the risk of heart attack, … Continue reading

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A Note About Dr. Bestermann’s Article

From Brian – The germ of today’s extremely provocative post by Bill Bestermann, MD was the moment in early May when he learned that my wife, Elaine, had primary peritoneal (ovarian) cancer. Bill’s focus for many years had been on … Continue reading

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Metformin, Asymmetric Dimethylarginine, and Cancer : The Keys to the Kingdom or a Tool to Pick the Lock?

WILLIAM BESTERMANN “The human body is composed of four cardinal fluids called humors….In the normal body, these four fluids were held in perfect if somewhat precarious balance. In illness, this balance was upset by the excess of one fluid.” Hippocrates … Continue reading

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Why We Still Kill Patients: Invisibility, Inertia, And Income

MICHAEL MILLENSON Originally Published 12/6/10 on the Health Affairs Blog here. A recent front-page article [1] in the New York Times conveyed grim news about patient safety. The first large-scale study [2] of hospital safety in a decade concluded that … Continue reading

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The Urgent Science of Chronic Medical Conditions: An Introduction

As I was developing this site, I mentioned it to my good friend Bill Bestermann. Dr. Bestermann is a very progressive, leading edge and nationally recognized vascular physician. When you talk with Bill, it’s very clear that it really is … Continue reading

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The New Science of Vascular Disease

This article, published almost two years ago – on C&C, we’ll refer to these as Recycled but Relevant – is a perfect opening to our Urgent Science section. If you agree that this kind of review article can be useful to … Continue reading

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How Most Fatal Heart Attacks Actually Happen

This 28 second video illustrates the kind of event that Tim Russert experienced, and that is described in Dr. Bestermann’s article above.

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