A Note About Dr. Bestermann’s Article

From Brian – The germ of today’s extremely provocative post by Bill Bestermann, MD was the moment in early May when he learned that my wife, Elaine, had primary peritoneal (ovarian) cancer. Bill’s focus for many years had been on vascular disease, but he dove into the literature on cancer, metformin and ADMA, and was energized by what he found.

He called a few days later and asked two questions. ”Did you know that diabetics on metformin get cancer at half the incidence of those not on metformin? Or that diabetics with breast cancer on metformin have their cancers ameliorate at triple the rate of those who are not on it?” I didn’t, but these facts intrigued Dr. Bestermann enough that he relentlessly pursued the science.

The article below, not original research but an important synthesis that leads us to a new understanding, is what came out of that effort. It’s message is ground-breaking – genuinely a paradigm shift in how we might think about chronic disease – and is an specifically aimed at practicing physicians. We have provided all citations, with links, not only to allow verification of source information, but also allow the interested reader to dive deeply into the topic. We are well aware that the science in this piece may be beyond lay readers, and we apologize for this divergence from a more general format.

We are delighted and humbled that Dr. Bestermann has allowed us to publish this piece here. It has been peer reviewed and found to be sound by several capable physician-scientists. One of the goals of Care & Cost is to make the science that can impact clinical practice immediately available.

That said, I believe the content in an article of this caliber and potential impact should also be recast and allowed to work through the more traditional physician publication machinery as well.

Metformin, Asymmetric Dimethylarginine, and Cancer : The Keys to the Kingdom or a Tool to Pick the Lock?

WILLIAM BESTERMANN

“The human body is composed of four cardinal fluids called humors….In the normal body, these four fluids were held in perfect if somewhat precarious balance. In illness, this balance was upset by the excess of one fluid.”

Hippocrates

This review is about metformin and cancer, but within a much broader context. It points to an important new science involving critical common core pathways that underlie the origins of multiple common chronic conditions. These pathways involve traditional signaling modifications like phosphorylation, but they also involve a fascinating new science of epigenetics and the methylation of proteins that are involved in inappropriate gene activation.

Continue reading “Metformin, Asymmetric Dimethylarginine, and Cancer : The Keys to the Kingdom or a Tool to Pick the Lock?”

The Makings of A Great Outcome

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ElaineLast week my wife and best friend, Elaine, had massive abdominal surgery. We fully expected her to be an inpatient for a week, but she was home in four and half days. To watch her recover was to see what happens when everything converges: the deep knowledge and skills of excellent, humane physicians; a capable, caring clinical staff; wonderful new technologies; and a lifetime of eating right, being fit and tending to one’s health.

Continue reading “The Makings of A Great Outcome”